Vanicoside B ( —— )

产品货号. M32656 CAS No. 155179-21-8

COA

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HNMR

HPLC

MSDS

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产品名称

Vanicoside B
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Vanicoside B is a natural product for research related to life sciences.
产品描述

Vanicoside B is a natural product for research related to life sciences.
体外实验

Western Blot Analysis Cell Line:MDA-MB-231 cells and HCC38 cells Concentration:0, 2.5, 5, 10 μM Incubation Time:48 hours Result:Increased cleaved PARP, and p27 protein expressions, but decreased Skp2 protein level.Suppressed CDK8 target genes and the expression of EMT-associated proteins.Suppressed the expression of the cell proliferation marker Ki-67 in tumor tissues, also significantly suppressed the expressions of p-STAT1 (S727) and AXL.Cell Cycle Analysis Cell Line:MDA-MB-231 cells and HCC38 cells Concentration:0, 2.5, 5, 10 μMIncubation Time:72 hours Result:Inhibited cell cycle at sub-G1 phase.
体内实验

Animal Model:MDA-MB-231 cell-implanted xenograft mouse modelDosage:5 mg/kg, 20 mg/kg Administration:Intraperitoneal injection; 3 times per week over 4 weeks Result:Significantly reduced tumor volumes at 5 mg/kg and 20 mg/kg by 53.85% and 65.72%, respectively.
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